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COMPLEMENT C3 NEPHRITIC FACTOR
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DeCS
Descriptor
English
:
Complement C3 Nephritic Factor
Descriptor
Spanish
:
Factor Nefrítico del Complemento 3
Descriptor
Portuguese
:
Fator Nefrítico do Complemento 3
Tree Number:
D12.776.124.486.274.920.287
D12.776.124.486.485.114.323.300
D12.776.124.790.651.114.323.300
D12.776.377.715.548.114.323.300
Definition
English
:
An IgG autoantibody against the ALTERNATIVE
COMPLEMENT C3
CONVERTASE (C3bBb), found in
serum
of
patients
with MESANGIOCAPILLARY
GLOMERULONEPHRITIS
. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous
COMPLEMENT ACTIVATION
and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Pharmacological Action:
Complement Inactivating Agents
Immunologic Factors
History Note
English
:
2006 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22147
Unique Identifier:
D003178
Occurrence in VHL
:
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